From Biocompatibility to Immune Engineering

Immune engineering: from systems immunology to engineering immunity.

The smallpox vaccine represents the earliest attempt in engineering immunity. The recent success of chimeric antigen receptor T cells (CAR-T cells) in cancer once again demonstrates the clinical potential of immune engineering. Inspired by this success, diverse approaches have been used to boost various aspects of immunity: engineering dendritic cells (DCs), natural killer (NK) cells, T cells, ...

Biocompatibility of Carbon Nanotubes for Cartilage Tissue Engineering

Carbon nanotubes (CNT) have the potential to become an important component of scaffolding in tissue engineering, due to their unique physical properties. However, one major limitation of CNTs that must be overcome is their inherent cytotoxicity. In this study, we assessed the long-term biocompatibility of CNTs for chondrocyte growth. The effect of CNTs on chondrocyte viability and biochemical d...

Engineering an Immune System1

from linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar

chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...

CRISPR-Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome Engineering.

The field of biology has been revolutionized by the recent advancement of an adaptive bacterial immune system as a universal genome engineering tool. Bacteria and archaea use repetitive genomic elements termed clustered regularly interspaced short palindromic repeats (CRISPR) in combination with an RNA-guided nuclease (CRISPR-associated nuclease: Cas) to target and destroy invading DNA. By choo...